This is the only nonsurgical method to reduce fats. It is based on the natural polyene phosphatidylcholine, a cholesterol-reducing injection for the treatment of hyperlipidemia, which is mixed with a certain formulation and directly injected to subcutaneous fat deposits to damage the cell membrane of adipocytes, thus rendering the necrosis of adipocytes, followed by automatic emulsification and lysis before they are excreted into the lymph circulation and metabolized outside the human body by the liver. Treatment results are only seen after the slow excretion of adipocytes via physical metabolism, so there is a waiting period of 1–2 weeks after each injection, and patients generally need to receive more than 3–4 injections to attain expected results. Because of its relatively long treatment period and different degrees of fat reduction due to individual condition, Dr. Chuang recommends the application of the injection to regional obese parts in no need of large-area liposuction or superficial fat deposits difficult to be distinctly improved by liposuction, such as the chin, cheeks, jowls, upper back, accessary breasts, or even larger areas such as the upper arms, waists, abdomen, knees, calves, or parts of thighs.

Compared with liposuction, lipodissolve injection lyses or damages adipocytes, but it is different in the mechanism of excretion of fats, so it should be correctly injected into the fat layer to obtain maximal results. Its advantages are imperceptible progressive results, almost no recovery period or swelling, and high flexibility in use by injection in a small part at the patient’s discretion, while the disadvantages are that results seem to be seen relatively slowly and may vary along with individuals. The long-term or repeated injections usually cost a lot; thus, it is unable to completely replace fat reduction surgery like liposuction. Besides, it is different from epidermal mesoderm treatment (mesotherapy) in the injection of drugs into the superficial skin layer and is not disputed as it is less likely to cause skin necrosis and complications; thus, as long as patients have normal liver functions and no underlying endocrine diseases, it achieves fat volume loss from a certain site by the injection of a safe dose and provides a noninvasive fat reduction option for those unnecessary to undergo liposuction.